The amyloid-β precursor protein: integrating structure with biological function
نویسندگان
چکیده
منابع مشابه
The amyloid-beta precursor protein: integrating structure with biological function.
Proteolytic processing of the amyloid-beta precursor protein (APP) generates the Abeta amyloid peptide of Alzheimer's disease. The biological function of APP itself remains, however, unclear. In the current review, we study in detail the different subdomains of APP and try to assign functional significance to particular structures identified in the protein.
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2005
ISSN: 0261-4189
DOI: 10.1038/sj.emboj.7600860